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Université de Bordeaux
LabEx COTECluster of Excellence
Cluster of excellence

UMR CENBG – TEAM IPCV (Bio Physics and Chemistry Interface)

UMR CENBG – TEAM IPCV (Bio Physics and Chemistry Interface)

The IPCV (Bio Physics and Chemistry Interface) belongs to CENBG (Nuclear Research Centre of Bordeaux Gradignan, which is a Joint Research Unit (UMR) of CNRS and INC (National Institute of Chemistry), and University of Bordeaux 1.

IPCV is involved in the study and modelling of the impact of physical and chemical agents: ionizing radiation, inorganic contaminants and nanoparticles. The team is strongly involved in AIFIRA platform (Interdisciplinary Applications of Ion Beam Analysis) for the development and application of multidisciplinary research using a 3.5 MV particle accelerator held at CENBG. Using a combination of chemical imaging methods, this instrument is the gold standard for the quantification of chemical elements at cellular level. From using the ion nanobeam at the AIFIRA facility, it is possible to identify the subcellular location of chemical elements in connection with a specific biological activity. This provides information about the metabolic and detoxification processes. The intracellular localization of exogenous compounds can be further improved through the development of an X-ray emission tomography technique that gives access to the 3D elemental distribution of the sample (PIXEtomography). This work reached a milestone in 2008 when the first quantitative chemical mapping of a cryofixed cell was obtained in a tomographic slice.

Contribution to  LabEx

IPCV will be involved in the characterisation of inorganic contaminants (trace metals and nanoparticles) in bio-environmental samples at high spatial resolution and high sensitivity using the ion beam nanoprobe at the AIFIRA facility. This is a near unique facility used worldwide to assess the chemical distribution of trace inorganic elements and nanoparticles in single cells. Only one other such nanoprobe exists in Europe, in Germany. Compared to other methods and because it can identify their intracellular distribution quantitatively, this analytical tool offers a real advantage for the study of mechanisms of toxicity of metals and nanoparticles.

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